RecruitingNot ApplicableNCT06270667

Effects of Exercise Training in Survivors of Lymphoma

The LYMfit Study: Exercise Training to Prevent Cardiovascular Disease in Lymphoma Survivors

Sponsor

Norwegian School of Sport Sciences

Enrollment

280 participants

Start Date

Mar 20, 2024

Study Type

INTERVENTIONAL

Conditions

Cardiotoxicity Chemotherapeutic Toxicity Lymphoma Cardiovascular Diseases Physical Exercise

Summary

This study aims to compare the effects of aerobic exercise with or without addition of resistance exercise to usual care in individuals treated with anthracyclines for lymphomas and to compare exercise effects to age- and sex-matched individuals with no prior history of malignant diseases.

Eligibility

Min Age: 20 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether a structured exercise program can improve heart health and overall fitness in people who have survived lymphoma (a type of blood cancer). Researchers are especially interested in people who received a chemotherapy drug called anthracycline, which can sometimes affect the heart. **You may be eligible if...** - You have been diagnosed with Hodgkin lymphoma or aggressive non-Hodgkin lymphoma - You completed treatment 2 to 5 years ago with no relapse - You received anthracycline chemotherapy - You currently exercise fewer than 75 minutes per week **You may NOT be eligible if...** - Your lymphoma has come back since your original diagnosis - You have been diagnosed with another cancer - You have other conditions that prevent you from safely exercising Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALAerobic Exercise

Participants receive twice weekly supervised aerobic treadmill-based exercise sessions for five months. Session duration varies from 20 to 60 minutes, including warm-up, with exercise intensity ranging from 60 to 95% of peak heart rate. Maximal exercise capacity (VO2peak and peak heart rate) will be determined by the CPET performed by certified exercise physiologists at baseline.The exercise prescription will be sequenced so that the exercise intensity and -duration of each exercise varies within each week, leading to an accumulative increase in weekly exercise volume throughout the intervention. This intervention is also given to the Active Comparator group (i.e. non-cancer reference group)

BEHAVIORALCombined Aerobic and Resistance Exercise

Twice weekly, supervised combined aerobic and resistance exercise sessions will be offered to participants. Participants randomized to the combined aerobic and resistance training group will follow the same aerobic exercise prescription as described for the Aerobic Exercise arm. In addition, participants in this group will perform five resistance exercises after the aerobic sessions. The resistance exercises will be leg press, knee extension, and calf rise, followed by seated row and chest press. Following familiarization, the training load will progressively increase following a linear periodization model throughout the intervention. exercise prescription will be sequenced so that the exercise intensity and -duration of each exercise varies within each week, leading to an accumulative increase in weekly exercise volume throughout the intervention. Only Lymphoma participants can be randomized to this arm.