Effects of Exercise Training in Survivors of Lymphoma
The LYMfit Study: Exercise Training to Prevent Cardiovascular Disease in Lymphoma Survivors
Norwegian School of Sport Sciences
280 participants
Mar 20, 2024
INTERVENTIONAL
Conditions
Summary
This study aims to compare the effects of aerobic exercise with or without addition of resistance exercise to usual care in individuals treated with anthracyclines for lymphomas and to compare exercise effects to age- and sex-matched individuals with no prior history of malignant diseases.
Eligibility
Inclusion Criteria7
- Listed in relevant registers
- Confirmed lymphoma diagnosis (i.e., Hodgkin lymphoma and aggressive non-Hodgkin lymphoma)
- Completed treatment in the past two to five years without relapse or second cancer
- Previous anthracycline treatment with or without mediastinal radiation
- No severe cancer-related fatigue (per self-report)
- Currently not performing \>75 minutes/week of aerobic exercise
- Willing and able to adhere to all study procedures.
Exclusion Criteria9
- Relapse since diagnosis
- A history, or current presence, of another diagnosis of invasive cancer of any kind
- Presence of any uncontrolled- or recent cardiovascular disease
- Has undergone heart surgery
- Uses a pacemaker
- Pregnancy
- Unable to read and understand Swedish (applicable for the Swedish site only)
- Unable to read and understand Norwegian (applicable for the Norwegian site)
- Any physical or mental health condition restricting adherence to study protocol
Interventions
Participants receive twice weekly supervised aerobic treadmill-based exercise sessions for five months. Session duration varies from 20 to 60 minutes, including warm-up, with exercise intensity ranging from 60 to 95% of peak heart rate. Maximal exercise capacity (VO2peak and peak heart rate) will be determined by the CPET performed by certified exercise physiologists at baseline.The exercise prescription will be sequenced so that the exercise intensity and -duration of each exercise varies within each week, leading to an accumulative increase in weekly exercise volume throughout the intervention. This intervention is also given to the Active Comparator group (i.e. non-cancer reference group)
Twice weekly, supervised combined aerobic and resistance exercise sessions will be offered to participants. Participants randomized to the combined aerobic and resistance training group will follow the same aerobic exercise prescription as described for the Aerobic Exercise arm. In addition, participants in this group will perform five resistance exercises after the aerobic sessions. The resistance exercises will be leg press, knee extension, and calf rise, followed by seated row and chest press. Following familiarization, the training load will progressively increase following a linear periodization model throughout the intervention. exercise prescription will be sequenced so that the exercise intensity and -duration of each exercise varies within each week, leading to an accumulative increase in weekly exercise volume throughout the intervention. Only Lymphoma participants can be randomized to this arm.
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT06270667