RecruitingPhase 1NCT06271252

A Study to Evaluate the Safety, PK/PD of (OriCAR-017) in Subjects With RR/MM - RIGEL Study

A Phase I/II, Open-label, Multicenter Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of Anti-GPRC5D CAR-T Cell Product (OriCAR-017) in Subjects With Relapsed/Refractory Multiple Myeloma.


Sponsor

OriCell Therapeutics Co., Ltd.

Enrollment

81 participants

Start Date

Apr 3, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The is a first clinical study for Oricell Therapeutics Inc. in the United States to evaluate the safety, PK, PD and preliminary efficacy of our anti-GPRC5D cell product (OriCAR-017) in subjects with relapsed/refractory multiple myeloma. RIGEL Study


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new CAR T-cell therapy called OriCAR-017 for people with relapsed or refractory multiple myeloma — a blood cancer that has come back or stopped responding to treatment. CAR T-cell therapy engineers your own immune cells to attack cancer cells. **You may be eligible if...** - You are between 18 and 75 years old - You have been diagnosed with multiple myeloma that has relapsed or not responded to at least 3 prior treatments - You have received prior BCMA-targeted therapy - Your expected survival is more than 12 weeks **You may NOT be eligible if...** - You have active infections or severe organ problems - You have had recent major surgery - You cannot tolerate the required procedures Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGOriCAR-017

Anti-GPRC5D CAR-T cell product


Locations(1)

Northside Hospital

Atlanta, Georgia, United States

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NCT06271252


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