Testing the Role of Anti-fungal Therapy in Improving the Response to Therapies for Crohn's Disease

This study is testing whether adding an antifungal medication (fluconazole) to standard Crohn's disease treatment can improve how well the treatment works. Researchers think that fungal overgrowth in the gut may be interfering with Crohn's disease therapies. **You may be eligible if...** - You are at least 18 years old - You have mild to moderate Crohn's disease **You may NOT be eligible if...** - You have used antifungal medication in the past month - You are allergic to fluconazole - You have liver disease, cirrhosis, or abnormal liver blood tests - You take medications that dangerously interact with fluconazole - You are pregnant or breastfeeding - You have severe Crohn's disease or need surgery soon - You have narrowing (strictures) in your intestine causing symptoms - You have a pouch (pouchitis) or an ostomy - You have an active fungal infection - You have low potassium levels, advanced heart failure, or kidney problems Talk to your doctor to see if this trial is right for you.