RecruitingNot ApplicableNCT06276400

LPFC Organization in Emotion-Duration Difference Estimation

Lateral Prefrontal Organization in Emotion: Representational and Causal Mechanism - Duration Difference Estimation

Sponsor

University of California, Santa Barbara

Enrollment

50 participants

Start Date

Jan 29, 2024

Study Type

INTERVENTIONAL

Conditions

Healthy

Summary

To support optimal behavior in daily life, goals and responses following emotional events should ideally incorporate not only the valence and intensity of prior emotional episodes but also their temporal features, such as the relative duration of positive vs. negative attributes. However, how specific brain regions contribute to the integration of temporal and emotional information and promote goal-directed response remains unknown. The goal of this study is to examine how specific brain regions track both emotional and temporal information of dynamic emotional events to inform other related brain regions to guide goal-oriented and context-appropriate actions. The investigators will scan healthy human participants using functional MRI (fMRI) while they view emotional image sequences and track the associated emotional and temporal (duration) information, and act accordingly. The investigators will employ multivariate patterns analysis and pattern similarity analysis to identify brain regions that represent (can decode) emotion, time, and their combined signals, as well as brain regions that represent the associated action goal. In addition, to infer the causal contributions of these brain regions in forming task-relevant representations (emotion, time, and action goal), the same participants will be recruited to receive transcranial magnetic stimulation (TMS) in these regions.

Eligibility

Min Age: 18 YearsMax Age: 45 Years

Inclusion Criteria4

right-handed
between the ages of 18 and 45
be a fluent English speaker
have normal to corrected-to-normal vision.

Exclusion Criteria9

if they report a current or prior diagnosis of a psychiatric disorder requiring hospitalization and/or are currently using psychiatric medication; o If they report a history of or current neurological disease (i.e., stroke, concussion, epilepsy, major head trauma, complicated migraine);
If they ever had a seizure;
If they have a family history of epilepsy or seizure disorders;
If they have a history of fainting;
If they are sleep deprived (TMS only);
If they have a history of prior surgery with metal clips, implants, devices, prosthetics, cardiac or neural implants (e.g., pacemaker; neurostimulator), or cochlear implants;
If they are unable to safely and comfortably complete an MRI: have metal in the body, recent surgery, presence of surgically implanted devices not cleared for MRI, extreme claustrophobia, if they report tattoos of the head or neck region, non-removable metal piercing anywhere on the body
Women will be asked to self-report their pregnancy status and have the option to take a pregnancy test if they wish. If there is a chance a participant is pregnant, they will not be scanned.
As part of the newly adopted UCSB BIC prescreening procedure, participants will be asked about their history of hearing issues (including loss, hyperacuity, sensitivity to loud noises, history of tinnitus (ringing in ears), job with high noise exposure, and chronic migraines. Participants will be excluded if one or more hearing issues are reported.

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Interventions

OTHEREmotion valence

Positive vs. Negative (temporally extended sequence)

OTHERTime

∆ Temporal evidence (i.e. relative time difference of stimulus-type exposure across a sequence: 1200 vs. 1800)

DEVICETMS Stimulation

FPl vs. mid-LPFC vs. non-PFC Control (S1); Specific LPFC region (vs. non-PFC active Control) function is manipulated with an inhibitory TMS protocol (cTBS).