Vabb After Neoadjuvant Therapy to Avoid Surgery-pCR to Avoid Breast Surgery

This trial is exploring whether patients with early-stage breast cancer who have a complete response (no remaining cancer cells) after chemotherapy given before surgery might be able to skip the surgery altogether. Researchers use a vacuum-assisted biopsy device (VABB) to check for remaining cancer at the original tumor site. **You may be eligible if...** - You are over 18 years old - You have a single breast tumor (non-special type) that is HER2-positive or triple-negative, classified as T1 or T2 with no lymph node spread (N0) - You have received at least 12 weeks of neoadjuvant (pre-surgery) chemotherapy - You were a candidate for breast-conserving surgery - A marker was placed in the tumor before chemotherapy to track the tumor bed **You may NOT be eligible if...** - Your cancer involves both breasts or multiple areas - You have microcalcifications visible on mammogram - You have DCIS (ductal carcinoma in situ) alongside your cancer - You have a history of previous breast cancer - You have a medical or psychiatric condition that prevents protocol adherence Talk to your doctor to see if this trial is right for you.