RecruitingNCT06287788

A Mucosal Contouring Method Based on Swallowing-induced Breakthrough Pain for Radiation-induced Oropharyngeal Mucositis

The Prediction of a Mucosal Contouring Method Based on Swallowing-induced Breakthrough Pain for Radiation-induced Oropharyngeal Mucositis in Patients With Nasopharyngeal Carcinoma: an Observational Study


Sponsor

Nanfang Hospital, Southern Medical University

Enrollment

240 participants

Start Date

Mar 1, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The performance of the predictive models for severe oropharyngeal mucositis established using current oral mucosal contouring method was unsatisfactory in nasopharyngeal carcinoma (NPC). Whereas the predictive model of a mucosal contouring method based on swallowing-induced breakthrough pain exhibited better overall performance. The aim of this prospective, multicenter, observational study was to further explore the predictive efficacy of this mucosal delineation method for radiation-induced oropharyngeal mucositis in NPC.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is developing a radiation treatment planning method that uses patients' self-reported pain during swallowing to more precisely target the most painful areas inside the mouth and throat, potentially reducing side effects during cancer treatment. **You may be eligible if...** - You are 18 or older - You have been diagnosed with nasopharyngeal carcinoma (a type of head and throat cancer) confirmed by biopsy - You are currently undergoing radiation therapy or combined radiation and chemotherapy - You have complete records of your mouth/throat mucositis grading and pain ratings **You may NOT be eligible if...** - You have poor oral hygiene or untreated dental disease or metal dental restorations - You have uncontrolled heart disease or poorly controlled diabetes - Your body mass index (BMI) is below 18.5 (underweight) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Southern Medical University

Guangzhou, Guangdong, China

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NCT06287788


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