RecruitingNCT06308328

A Real-world Observational Study of a Mucosal Contouring Method for Radiation-induced Oropharyngeal Mucositis

A Real-world Observational Study of a Mucosal Contouring Method Based on Swallowing-induced Breakthrough Pain for Predicting Radiation-induced Oropharyngeal Mucositis in Patients With Nasopharyngeal Carcinoma


Sponsor

Nanfang Hospital, Southern Medical University

Enrollment

718 participants

Start Date

Apr 1, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The performance of the predictive models for the occurrence and severity of oropharyngeal mucositis established using either oral cavity contouring method or mucosa surface contouring method was unsatisfactory in nasopharyngeal carcinoma (NPC). Whereas the predictive model of a mucosal contouring method based on swallowing-induced breakthrough pain exhibited better overall performance in locally advanced NPC. Therefore, the investigators aimed to conduct a prospective, multicenter, real-world observational study to further assess the predictive efficacy of this mucosal delineation method for radiation-induced oropharyngeal mucositis in NPC.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study observes patients receiving radiation treatment for nasopharyngeal cancer (a type of head and neck cancer) to evaluate a new method of planning radiation that aims to reduce painful mouth sores (mucositis) — one of the most common and painful side effects of head and neck radiation therapy. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with nasopharyngeal carcinoma (a cancer at the back of the nose/throat) - You are currently undergoing radical radiotherapy or combined chemotherapy and radiation - Your treatment records of mouth sore grading and pain during swallowing are complete and regularly documented **You may NOT be eligible if...** - You have poor dental hygiene, untreated gum disease, or metal dental work - You have uncontrolled heart disease or poorly managed diabetes - Your body mass index (BMI) is below 18.5 (underweight) - The study researchers determine you are unsuitable for other reasons Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(10)

Affiliated Cancer Hospital & Institute of Guangzhou Medical University

Guangzhou, Guangdong, China

Nanfang hospital, Southern medical university

Guangzhou, Guangdong, China

Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University

Guangzhou, Guangdong, China

Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, China

The First Affiliated Hospital, Sun Yat-sen University

Guangzhou, Guangdong, China

Yuebei People's Hospital

Shaoguan, Guangdong, China

Peking University Shenzhen Hospital

Shenzhen, Guangdong, China

The Fifth Affiliated Hospital, Sun Yat-sen University

Zhuhai, Guangdong, China

Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality, China

Sichuan Cancer Hospital

Chengdu, Sichuan, China

View Full Details on ClinicalTrials.gov

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NCT06308328


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