Green Propolis Extract and Royal Jelly in Hypertensive Patients and/or With Chronic Kidney Disease
Association of Green Propolis Extract and Royal Jelly to Modulate Inflammation and Oxidative Stress in Hypertensive Patients and/or With Chronic Kidney Disease
Universidade Federal Fluminense
153 participants
Oct 1, 2024
INTERVENTIONAL
Conditions
Summary
This work aims to evaluate the effects of the association of green propolis extract with royal jelly on inflammation and oxidative stress in participants with chronic kidney diseases (CKD) and Systemic arterial hypertension (SAH), in a longitudinal, randomized, double-blind, placebo-controlled clinical trial that will be carried out for 2 months.
Eligibility
Inclusion Criteria4
- patients in stages 3 and 5 of CKD (GFR from 15 to 59 mL/min),
- patients receiving ambulatorial nutrition treatment at least 6 months
- patients on regular Hemodialysis treatment for at least 6 months
- patients using one to three antihypertensive drugs
Exclusion Criteria10
- autoimmune and infectious diseases,
- diabetes
- cancer
- AIDS
- pregnant women
- patients using catabolic drugs or antibiotics;
- patients with catheter access to hemodialysis;
- patients using antioxidant vitamin supplements, prebiotics, probiotics, symbiotic,
- Patients on regular intake of propolis who are allergic to corn starch or report being allergic to bee stings.
- patients with acute myocardial infarction (AMI) and/or cerebrovascular accident (CVA)
Interventions
The participants will consume 4 capsules a day, providing daily royal jelly in an amount of 100 mg/day plus 500 mg/day of propolis together, for 2 months.
The participants will consume 1 capsules a day, providing daily royal jelly in an amount of 100 mg/day, for 2 months.
The participant will consume 4 capsules a day of placebo, for 2 months.
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06288204