RecruitingNot ApplicableNCT06288204

Green Propolis Extract and Royal Jelly in Hypertensive Patients and/or With Chronic Kidney Disease

Association of Green Propolis Extract and Royal Jelly to Modulate Inflammation and Oxidative Stress in Hypertensive Patients and/or With Chronic Kidney Disease

Sponsor

Universidade Federal Fluminense

Enrollment

153 participants

Start Date

Oct 1, 2024

Study Type

INTERVENTIONAL

Conditions

Cardiovascular Diseases Hypertension Chronic Kidney Diseases

Summary

This work aims to evaluate the effects of the association of green propolis extract with royal jelly on inflammation and oxidative stress in participants with chronic kidney diseases (CKD) and Systemic arterial hypertension (SAH), in a longitudinal, randomized, double-blind, placebo-controlled clinical trial that will be carried out for 2 months.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether supplements of green propolis extract and royal jelly (natural bee products) can reduce inflammation and improve health outcomes in patients with chronic kidney disease (CKD) or those on hemodialysis who also have high blood pressure. **You may be eligible if...** - You have CKD at stages 3–5 (including those on hemodialysis for at least 6 months) - You are being treated with 1 to 3 blood pressure medications - You have been receiving nutritional care for at least 6 months **You may NOT be eligible if...** - You have diabetes, cancer, AIDS, or autoimmune/infectious diseases - You are pregnant - You are currently taking antibiotics or have taken them recently - You take antioxidant supplements or already consume propolis regularly - You are allergic to bee stings or corn starch - You have had a recent heart attack or stroke Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTPropolis associated with Royal Jelly

The participants will consume 4 capsules a day, providing daily royal jelly in an amount of 100 mg/day plus 500 mg/day of propolis together, for 2 months.

DIETARY_SUPPLEMENTRoyal Jelly

The participants will consume 1 capsules a day, providing daily royal jelly in an amount of 100 mg/day, for 2 months.

DIETARY_SUPPLEMENTPlacebo

The participant will consume 4 capsules a day of placebo, for 2 months.