RecruitingNCT06288763

Nerve Transfer to Improve Function in High Level Tetraplegia

Nerve Transfer to Restore Upper Limb Function and Quality of Life in High Tetraplegia

Sponsor

Washington University School of Medicine

Enrollment

30 participants

Start Date

Feb 5, 2024

Study Type

OBSERVATIONAL

Conditions

Cervical Spinal Cord Injury

Summary

The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury. Participants will: * undergo standard of care pre- and post-op testing and study exams * complete pre- and post-questionnaires * undergo standard of care nerve transfer surgeries * follow-up with surgeon at 6/12/18/24/36 and potentially at 48 months * attend therapy at local therapist for up to 2 years postop.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria7

years of age
High cervical SCI (motor level C1-C4)
Motor complete SCI AIS grade A-B
Plateaued spontaneous recovery for at least 6 months of non-operative therapy
SCI greater than 6 months and fewer than 60 months since injury
At least MRC 4/5 donor strength
Mentally and physically willing and able to comply with evaluations

Exclusion Criteria8

Active infection at the operative site or systemic infection
Any return or ongoing recovery of distal motor function
Significant joint contractures and/or limitations in passive range of motion in the arm
Mentally or physically compromised making it impossible to complete study activities
Immunologically suppressed
Currently undergoing long-term steroid therapy
Active malignancy
Pregnancy

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