RecruitingNCT06289374

Longitudinal Assessment of Biomarkers After Oesophagogastric Cancer Surgery

The LABS Study: Longitudinal Assessment of Biomarkers After Oesophagogastric Cancer Surgery (BIORESOURCE 2: Longitudinal)

Sponsor

Imperial College London

Enrollment

100 participants

Start Date

Feb 1, 2025

Study Type

OBSERVATIONAL

Conditions

Gastric Adenocarcinoma Oesophageal Adenocarcinoma

Summary

Oesophagogastric cancer (cancer of the gullet and stomach) is the fifth most common cancer in England and Wales with 16,000 new cases diagnosed every year. Survival rates are poor with only 15% surviving beyond 5 years. There is also increasing research to understand the cancer biology and factors allowing cancers to progress. It is likely there is a relationship between the cancer-specific microbiome, cells related to inflammation, which promotes cancer progression. The BIORESOURCE 1 study has established a comprehensive resource of matched samples from patients with oesophageal and gastric cancer. This longitudinal study aims to obtain further matched biosamples in the follow-up period after cancer surgery to find biomarkers that may predict treatment response, recurrence and/or long term prognosis.

Eligibility

Min Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting blood and breath samples from patients with stomach or esophageal cancer over time after surgery, to identify biological markers that may help detect cancer recurrence earlier. **You may be eligible if...** - You are between 18 and 90 years old - You have been diagnosed with gastric (stomach) or esophageal adenocarcinoma (a specific cancer type confirmed by biopsy) - You were previously enrolled in the BIORESOURCE 1 study **You may NOT be eligible if...** - You have esophageal squamous cell carcinoma (a different cancer type) - You have had a previous stomach or esophageal surgery - You have had another cancer within the past 5 years - You have conditions that prevent you from providing breath samples - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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