RecruitingNCT06291311

Non-Invasive Plasma Treatment for Cervical Infections: Targeting High- and Low-Risk HPV Variants

Treatment of Infections of the Cervix Uteri With High- and Low-risk Variants of the Human Papillomavirus Using Non-invasive Physical Plasma


Sponsor

University Hospital Tuebingen

Enrollment

50 participants

Start Date

Dec 27, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

This is a prospective, single-center, observational proof-of-principle clinical trial at the Department of Women's Health of the University Hospital Tübingen.


Eligibility

Sex: FEMALEMin Age: 18 Years

Inclusion Criteria8

  • Age ≥ 18 years
  • mRNA or DNA-based virus detection by smear (also external findings)
  • Clearly visible transformation zone of the cervix and margins of the lesions corresponding to T1/T2
  • Written informed consent to participate in the study
  • Age ≥ 18 years
  • Swab-based mRNA or DNA-based virus detection (also external findings)
  • Clearly visible transformation zone of the cervix corresponding to T1/T2
  • Written informed consent to participate in the study

Exclusion Criteria3

  • Transformation zone not fully visible
  • Evidence of invasive disease
  • Serious cardiovascular diseases

Interventions

OTHERCold physical Plasma

The treatment is administered by either the supervising specialists or assistant doctors at the University Women's Hospital, under their supervision and authorization. It's important to note that the NIPP treatment is designed to be relatively brief, with a duration not exceeding 10-20 minutes.

OTHERControl group

A potential natural healing of the HPV infection will be anticipated


Locations(1)

University Hospital Tuebingen, Department of Women's Health

Tübingen, Germany

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NCT06291311


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