The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain
The Effect of Premedication With Trypsin, Bromelain and Rutoside Combination on the Success of IAN Block and Post Endodontic Pain in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial
Cairo University
120 participants
Jun 15, 2025
INTERVENTIONAL
Conditions
Summary
Pain is a very important factor in Endodontic treatment, Both intra- and Post-operatively. In case of symptomatic Irreversible pulpitis, a build up of inflammatory mediators makes it very difficult for the operator to reach the desired level of anesthesia in order to deliver a pain free treatment as well as to eliminate or at least reduce post-operative pain incidence and severity. therefore, a number of pre- medications was suggested with variable success rates. Therefore this trial aims at the use of a new category of anti-inflammatory medications which would be less harmful than the standard NSAIDs or steroids.
Eligibility
Inclusion Criteria5
- Patients with symptomatic irreversible pulpitis.
- Patients with active pain (moderate-to-severe) in mandibular molars.
- Males and females.
- Patient with the ability to understand and use pain scales.
- Patient who accepts to enroll to the study
Exclusion Criteria6
- Patients' allergies or any other contraindication to any of the used medications or mepivacaine.
- Pregnant and lactating females.
- Patients have been taking pain medication 12 hours earlier.
- Patient has more than one symptomatic mandibular tooth in the same quadrant.
- Patients with periradicular pathosis and/or radiolucency other than widened periodontal ligaments.
- Patients with contributory medical history (ASA\>II).
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Interventions
Flamogen is a combination of trypsin 48 mgs, bromelain 90mg and rutoside 100 mg in one tablet that provides an anti inflammatory, anti edematous activity. each patient will receive a single dose of 2 tablets one hour before treatment.
Non-steroidal anti inflammatory drug. cataflam is known for its potent anti inflammatory and analgesic properties. each patient will receive one tablet of cataflam 50 mg 1 hour before treatment.
Steroids are potent anti inflammatory drugs, patients are going to receive one tablet of 30 mg solupred one hour before treatment
A tablet of Compacted powdered milk
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06298383