Characterization of Exosomes Platelets-released
Centro Cardiologico Monzino
175 participants
Jul 8, 2021
OBSERVATIONAL
Conditions
Summary
Extracellular vesicles (EVs) play a key role in cell-to-cell communication. They are small vesicles that contain rich molecular cargo. Recently, they have been proposed as biomarkers for clinical diagnostics. EVs include three classes: small EVs (exosomes), large EVs (microparticles), and apoptotic bodies. Platelet-derived EVs (PEVs) are the most abundant class in human blood and can actively participate in numerous physiological and pathological processes. The information about the role of platelet exosomes in cardiovascular disease and the effect of antiplatelet agents on their release and content is very limited.
Eligibility
Inclusion Criteria1
- subjects without known pathologies
Exclusion Criteria14
- individuals with gastrointestinal diseases,
- individuals with history of hepatic diseases,
- individuals with history of urogenital diseases,
- individuals with history of hematological diseases,
- individuals with history of immunological diseases,
- individuals with history of renal diseases,
- individuals with history of metabolic diseases
- individuals with history of respiratory diseases
- individuals with history of cancer
- individuals with history of cardiovascular disease
- individuals having permanent organ damage
- individuals with major trauma in the last 6 months prior to enrollment
- individuals with surgery in the last 6 months prior to enrollment
- individuals taking medication in the 15 days prior to enrolment.
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Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06298682