PET Study to Evaluate Brain Receptor Occupancy, Safety and Pharmacokinetics of ITI-1284 in Healthy Subjects

This study uses PET brain scans to measure how much of a new experimental drug, ITI-1284, reaches and attaches to specific receptors in the brain in healthy volunteers. This helps determine the right dose for future studies. **You may be eligible if...** - You are a healthy male or female between 18 and 50 years old - Your BMI is between 18–32 kg/m² and you weigh at least 50 kg - You are willing to stay in the hospital research unit for the inpatient period of the study **You may NOT be eligible if...** - You have a significant medical condition (heart, liver, kidney, neurological, or immune disease) within the past 2 years - Your blood pressure, heart rate, or vital signs are outside of normal ranges at screening - You have a psychiatric history that could affect study participation - You have any contraindication to MRI or PET/CT scans (such as metal implants, claustrophobia, or inability to fit in the scanner) - You have abnormal results on MRI done before the study Talk to your doctor to see if this trial is right for you.