Cognitive Dysfunction in the Addictions Study - Project 4 (P4)
Assessing the Role of Repetitive Transcranial Magnetic Stimulation on Aberrant Executive Function in the Context of Major Depressive Disorder in Adult Outpatients Seeking Treatment for Alcohol Use Disorder
Centre for Addiction and Mental Health
40 participants
Feb 7, 2022
INTERVENTIONAL
Conditions
Summary
The prefrontal cortex, although well established as an efficacious target for the treatment of major depressive disorder (MDD), has recently come into favour as a therapeutic target for alcohol use disorders (AUD). Depressive symptoms are also highly prevalent in individuals with AUD. A number of cognitive and psychological processes stemming from the prefrontal cortex, a common treatment target for repetitive transcranial magnetic stimulation (rTMS), are disrupted in both MDD and AUD. The proposed study will enhance the development of theta burst stimulation (TBS) as a new intervention for AUD in the context of depressive symptoms and uses integrated TMS-EEG to identify neurophysiological targets of executive dysfunction in this disorder.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Theta-burst stimulation
Stimulation with double-sided B70-type coil
Locations(1)
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NCT06299787