RecruitingNot ApplicableNCT06299787

Cognitive Dysfunction in the Addictions Study - Project 4 (P4)

Assessing the Role of Repetitive Transcranial Magnetic Stimulation on Aberrant Executive Function in the Context of Major Depressive Disorder in Adult Outpatients Seeking Treatment for Alcohol Use Disorder


Sponsor

Centre for Addiction and Mental Health

Enrollment

40 participants

Start Date

Feb 7, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

The prefrontal cortex, although well established as an efficacious target for the treatment of major depressive disorder (MDD), has recently come into favour as a therapeutic target for alcohol use disorders (AUD). Depressive symptoms are also highly prevalent in individuals with AUD. A number of cognitive and psychological processes stemming from the prefrontal cortex, a common treatment target for repetitive transcranial magnetic stimulation (rTMS), are disrupted in both MDD and AUD. The proposed study will enhance the development of theta burst stimulation (TBS) as a new intervention for AUD in the context of depressive symptoms and uses integrated TMS-EEG to identify neurophysiological targets of executive dysfunction in this disorder.


Eligibility

Min Age: 18 YearsMax Age: 59 Years

Plain Language Summary

Simplified for easier understanding

This study investigates how thinking and memory problems (cognitive dysfunction) affect people who have both alcohol use disorder (AUD) and depression. Researchers are exploring whether a brain stimulation technique called TMS (transcranial magnetic stimulation) can help. Participants are outpatients already in treatment. **You may be eligible if...** - You are an outpatient between 18 and 59 years old - You have been diagnosed with alcohol use disorder (AUD) based on a clinical interview - You have not used alcohol or other substances (except nicotine or caffeine) for more than 1 month - You have been diagnosed with a current major depressive episode without psychotic symptoms - You are willing to keep your current antidepressant or AUD medications stable during the study - You meet safety requirements for TMS brain stimulation **You may NOT be eligible if...** - You use substances other than alcohol, nicotine, or caffeine - You do not meet TMS safety criteria - You are unable to follow the study schedule Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEintermittent theta burst stimulation

Theta-burst stimulation

DEVICESham stimulation

Stimulation with double-sided B70-type coil


Locations(1)

Centre for Addiction and Mental Health

Toronto, Ontario, Canada

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NCT06299787


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