RecruitingNot ApplicableNCT06302543

Treatment of Premature Ovarian Insufficiency Using Bone Marrow Cells

Treatment of Premature Ovarian Insufficiency Using Autologous Bone Marrow Concentrates Through Transvaginal Approach Under Ultrasound Guidance


Sponsor

abdulmajeed hammadi

Enrollment

10 participants

Start Date

Mar 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

investigator is doing single armed clinical interventional study to treat premature ovarian insufficiency with autologous bone marrow derived mononuclear cells to be given systematically and locally to the ovaries under ultrasound guidance with experienced gynecologist and to look for the results including: laboratory evidence through hormonal study ultrasound proof of ovarian follicle development. premature ovarian insufficiency is characterized by early loss of ovarian function (less than 40 years of age) manifested by menstrual irregularity or amenorrhea with elevated levels of gonadotropin hormones and low estrogen and anti-Mullerian hormone. Autologous use of stem cells from bone marrow are alternative safe minimal manipulative products that can provide a solution to this clinical problem without the need for oocyte donation program.


Eligibility

Sex: FEMALEMin Age: 30 YearsMax Age: 60 Years

Inclusion Criteria3

  • clinical diagnosis of premature Ovarian insufficiency.
  • ineffective hormonal therapy.
  • biochemical evidence of high gonadotropins.

Exclusion Criteria3

  • solid or hematological malignancies.
  • bleeding disorders.
  • rejection of the procedure.

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Interventions

PROCEDUREautologous bone marrow cells injection

under general anesthesia bone marrow aspiration done followed by cell concentration and transvaginal ovarian injection


Locations(1)

Ministry of Health

Baghdad, Iraq

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NCT06302543


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