Negative Serology by Immunoenzymatic Test (EIA) in HIV-infected Children Treated Early With Antiretroviral in the ANRS-Pediacam Study: Pathophysiological Mechanisms

This study investigates why some HIV-positive children who started antiretroviral treatment very early in infancy test negative on HIV antibody blood tests — even though they are still infected with the virus. Understanding this biological puzzle could lead to better diagnostic tools and insight into how the immune system responds to HIV in early life. **You may be eligible if...** - You are a child enrolled in the ANRS 12225 Pediacam III follow-up study - You have stored blood samples from the relevant study periods - For the 'case' group: you had at least one negative HIV antibody (ELISA) test result during follow-up despite being HIV-positive - For 'control' groups: you are HIV-positive with a positive test, HIV-negative born to a positive mother, or HIV-negative born to a negative mother **You may NOT be eligible if...** - You are not enrolled in the Pediacam study - Required blood samples are not available in the biobank Talk to your doctor to see if this trial is right for you.