Radiation Prior to TKI to Delay Progression in Advanced Driver-Mutated Non-small Cell Lung Cancers (RadiaNCe Lung X)

This study tests whether giving targeted radiation to the main lung tumor before starting a targeted therapy drug (TKI) in people with advanced, mutation-driven non-small cell lung cancer (NSCLC) can delay cancer progression. **You may be eligible if...** - You are 18 years or older - You have been confirmed to have non-small cell lung cancer with a specific driver mutation - You have advanced disease (stage IV or non-resectable stage IIIB/C) - You have an identifiable primary tumor in the lung - You have not yet received any targeted therapy for NSCLC (you may have had up to 2 cycles of standard chemotherapy) - You have not previously had radiation to the primary lung lesion **You may NOT be eligible if...** - You have already started targeted therapy for NSCLC - You have had prior radiation to the main lung tumor - Your cancer does not have a targetable driver mutation - Your general health is not sufficient to tolerate radiation and targeted therapy Talk to your doctor to see if this trial is right for you.