RecruitingNot ApplicableNCT06308094

320-detector Computed Tomography to Assess Myocardial Extracellular Volume Fraction in Patients With Atrial Fibrillation Before AF Ablation.

Sponsor

Johns Hopkins University

Enrollment

100 participants

Start Date

Apr 10, 2025

Study Type

INTERVENTIONAL

Conditions

Atrial Fibrillation

Summary

This study explores the relationship between myocardial fibrosis and patient outcomes in Atrial Fibrillation (AF), specifically after catheter ablation. It aims to use Cardiac CT, an accessible tool, to measure left ventricular extracellular volume (ECV) as an indicator of fibrosis. The study will assess if higher ECV levels correlate with increased risks of AF recurrence, hospitalization, and poor cardiac function recovery. Positive findings could make ECV a key factor in deciding AF treatment strategies.

Eligibility

Min Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This study uses an advanced CT scanner (with 320 detectors) to assess the amount of scar tissue in the heart muscle of people with atrial fibrillation (an irregular heartbeat) before they undergo a procedure to correct the rhythm. The goal is to see if CT imaging can help predict which patients will benefit most from the procedure. **You may be eligible if...** - You are at least 21 years old - You have been diagnosed with symptomatic atrial fibrillation (irregular heartbeat with symptoms) - Your cardiologist has determined you are a good candidate for an ablation procedure to treat your irregular heartbeat - You are already scheduled for a pre-procedure heart CT scan **You may NOT be eligible if...** - You have a known allergy to iodine contrast dye used in CT scans - You have poor kidney function - You are pregnant - You have had a heart transplant - You have a pacemaker, metal in your eye, a brain aneurysm clip, or mechanical heart valves containing metal - You experience severe claustrophobia - You have a serious irregular heartbeat called polymorphic ventricular tachycardia Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTCT

Pre-ablation CT is clinically acquired in patients undergoing catheter ablation. This study entails additional acquisition of the left ventricle to assess extracellular volume (ECV)