Transarterial Chemoembolization (TACE) Plus Bevacizumab for Liver Metastases
An Open-Label Pilot Study to Evaluate Efficacy and Safety of Bevacizumab Via Transarterial Chemoembolization (TACE) in Patients With Liver Metastases
Pardis Noor Medical Imaging and Cancer Center
40 participants
Jun 1, 2025
INTERVENTIONAL
Conditions
Summary
Trans arterial chemoembolization (TACE) has emerged as a treatment option for chemotherapy-refractory diseases in Liver metastases. By delivering chemotherapy agents directly to the tumor site, TACE can maximize local drug concentrations and reduce systemic adverse reactions. Bevacizumab is a monoclonal antibody that functions as an angiogenesis inhibitor. It works by slowing the growth of new blood vessels by inhibiting vascular endothelial growth factor A (VEGF-A). The application of Bevacizumab during TACE has not been reported. In this study, we will evaluate the the overall survival (OS)、efficacy, and safety of the application of Bevacizumab during TACE in patients with Liver Metastases by designing an open, single-arm phase II clinical study.
Eligibility
Inclusion Criteria7
- Confirmation of metastatic liver cancer via histological examination or a characteristic imaging profile on dynamic computed tomography (CT) scan or magnetic resonance imaging (MRI) without indications for surgical resection
- Eastern cooperative oncology group performance status (ECOGPS) of 0 or 1
- Liver function categorized as Child-Pugh class A or B
- Stable non-hepatic metastases, such as skeletal, pulmonary, or lymph node metastases
- Hepatic tumor burden below 70%
- Expected survival duration exceeding six months
- Laboratory findings meeting specific criteria, including platelet count \>50×109 /L, hemoglobin \>8.0 g/dL, ANC count ≥1.5 × 109/L, bilirubin \<51 mmol/L, alanine and aspartate aminotransferase \<3 times the upper limit of the normal range, and serum creatinine \<1.5 times the upper limit of the normal range.
Exclusion Criteria5
- Active infection
- Presence of severe comorbidities, such as hepatic encephalopathy, refractory ascites, and esophageal variceal bleeding
- Prior liver resection
- Previous TACE therapy received at other healthcare facilities
- Poor performance status (ECOGPS \> 1)
Interventions
Infusion of Bevacizumab-loaded hepaspher through transarterial chemoembolization.
Locations(1)
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NCT06311851