A Study of JMKX003948 Tablets in Patients With Renal Cell Carcinoma

This study tests a new oral drug called JMKX003948 in patients with advanced or metastatic clear cell kidney cancer (renal cell carcinoma). The goal is to evaluate how safe it is and whether it is effective at controlling cancer growth. **You may be eligible if...** - You are 18 years or older - You have been confirmed by biopsy to have locally advanced or metastatic clear cell renal cell carcinoma (kidney cancer) - You have at least one measurable tumor on imaging - Your life expectancy is 12 weeks or more - Your organ function (kidneys, liver, blood counts) is adequate **You may NOT be eligible if...** - You have active brain metastases (cancer spread to the brain) or cancer in the lining around the brain - You have received systemic immunotherapy or anticancer antibodies within 4 weeks before the first dose - You have not recovered from significant side effects of prior cancer treatment - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.