RecruitingPhase 2NCT06322238

Pharmacogenetic Panel to Prevent Adverse Drug Reactions in Daily Primary Care Practice:

A Multi-gene Pharmacogenetic Panel to Prevent Adverse Drug Reactions in Daily Primary Care Practice: Open-label, Mayo Clinic Multisite (Mayo Clinic Health System-Rochester Primary Care), Controlled, Implementation Study Taking the Results of the PREPARE Study Into Minnesota (PREPARE-Mayo)

Sponsor

Mayo Clinic

Enrollment

66 participants

Start Date

Dec 1, 2024

Study Type

INTERVENTIONAL

Conditions

Side Effect of Drug Pharmacogenomic Drug Interaction Ineffective Drug Action Drug Metabolism, Poor, CYP2D6-Related Drug Metabolism, Poor, CYP2C19-Related

Summary

The purpose of this study is to determine whether the implementation of pre-emptive pharmacogenomic (PGx) testing of a panel of clinically relevant PGx markers, to guide the dose and drug selection for 39 commonly prescribed drugs, will result in an overall reduction in the number of clinically relevant drug-genotype associated ADRs which are causally related to the initial drug of inclusion (referred to as 'index drug').

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying PGx panel test for people with drug metabolism, poor, cyp2c19-related, drug metabolism, poor, cyp2d6-related, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTPGx panel test

In this prospective, non-randomized, step-wedge design controlled clinical study (PREPARE-MAYO Rochester, Mayo Clinic Health System), pre-emptive genotyping of a panel of clinically relevant PGx-markers, for which CPIC guidelines are available.