Hypofractionated Post-prostatectomy Radiotherapy (HYPORT)for Localized Prostate Cancer

This study tests a shorter, more concentrated course of radiation therapy (called hypofractionated radiotherapy) given after prostate surgery (prostatectomy). This approach delivers higher doses per session over fewer weeks, which may be just as effective as standard longer radiation courses but more convenient. Researchers are studying its safety and how well it works. **You may be eligible if...** - You have had prostate cancer surgery (radical prostatectomy) - Your post-surgery pathology showed high-risk features (e.g., cancer at surgical margins, spread outside the prostate, or PSA levels rising after surgery) - You are in good general health (ECOG score 2 or less) - You are expected to live more than 5 years **You may NOT be eligible if...** - You have significant urinary problems after your prostate surgery - You have had previous pelvic radiation - You have another active cancer - Your cancer has spread to distant organs Talk to your doctor to see if this trial is right for you.