Suvorexant and Alcohol

Exclusion Criteria14

• Able to speak and read English.
• Not seeking treatment at the time of the study.
• Between the ages of 21 and 55 years.
• Engaging in at least one binge drinking episode, per the NIAAA definition, in the last 30 days.
• Fulfillment of moderate or severe DSM-5 diagnostic criteria for AUD based on computerized SCID results reviewed by a psychiatrist or psychologist.
• ECG, read by cardiologist, within normal limits.
• Body mass index of 19 - 35.
• Birthing individuals using an effective form of birth control and not pregnant or breast feeding.
• Judged by the medical staff to be psychiatrically and physically healthy (i.e., no current severe SUD or psychiatric diagnoses other than AUD or Tobacco Use Disorder; no current physical diagnoses that would interfere with study participation according to study physician judgment).
• Not currently physiologically dependent on any substances.
• Able to abstain from alcohol during admission (i.e., not physically dependent on alcohol and scores less than 8 on Clinical Institute Withdrawal Assessment for Alcohol \[CIWA-Ar\] at screening).
• Not currently taking any prescribed medications for a chronic condition (other than birth control).
• No indication of sleep apnea on the STOP-Bang questionnaire (score of 5 or greater).
• No contraindications/allergies to suvorexant.