RecruitingNot ApplicableNCT06328543

Itch Sensation Induced by Multiple Applications of Pruritogens (temporal Summation)

Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception

Sponsor

Aalborg University

Enrollment

26 participants

Start Date

Nov 1, 2024

Study Type

INTERVENTIONAL

Conditions

Histamine Cowhage

Summary

In This experiment, the investigators would like to design a new itch model based on the temporal summation of pruritic stimuli. The hypothesis behind this study (temporal summation) is that two overlapped applications of pruritogens will result in a higher itch sensation compared with a single application.

Eligibility

Min Age: 18 YearsMax Age: 60 Years

Inclusion Criteria3

Healthy men and women
years
Speak and understand Englis

Exclusion Criteria10

Pregnancy or lactation
Drug addiction defined as any use of cannabis, opioids, or other addictive drugs
Previous or current history of neurological (e.g. neuropathy), immunological (e.g. asthma, immune deficiencies, arthritis), musculoskeletal (e.g. muscular pain in the upper extremities,), cardiac disorder, or mental illnesses that may affect the results
Lack of ability to cooperate
Current use of medications that may affect the trial such as antihistamines, antipsychotics, and pain killers, as well as systemic or topical steroids
Skin diseases (e.g. atopic dermatitis, pruritus nodularis, eczema, psoriasis)
Moles, scars, or tattoos in the area to be treated or tested.
Consumption of alcohol or painkillers 24 hours before the study days and between these
Acute or chronic pain
Participation in other trials within one week of study entry (four weeks in the case of pharmaceutical trials)

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Interventions

OTHERHistamine

Histaminergic itch will be evoked by a 1% histamine solution. A droplet of histamine solution will be placed on the predetermined area on the forearm, and the SPT lancet will be pierced through the histamine.

OTHERCowhage

25 spicules will be inserted in the center of the predefined skin area on the mandibular area. The spicules will be gently rubbed for 15-20 seconds in circular motion to facilitate epidermal penetration.