RecruitingPhase 1Phase 2NCT06329882

Doxycycline in Type II Diabetes

Doxycycline in Combination With Sitagliptin on the Glycemic and Cardiac Indices in Patients With Type 2 Diabetes Mellitus


Sponsor

Mostafa Bahaa

Enrollment

60 participants

Start Date

Mar 30, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by hyperglycemia, weight loss, and cardio-metabolic complications. T2DM develops due to the progression of insulin resistance (IR), impairment of insulin insensitivity, and failure of the pancreatic β-cells to release sufficient amount of insulin in response to glucose burden


Eligibility

Min Age: 40 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether doxycycline — an antibiotic that also has anti-inflammatory properties — can help manage blood sugar levels in people newly diagnosed with type 2 diabetes. There is growing evidence that inflammation plays a role in diabetes, and researchers want to see if doxycycline's anti-inflammatory effects could provide a benefit beyond its antibiotic use. **You may be eligible if:** - You are male or female, over 40 years old - You have been newly diagnosed with type 2 diabetes - Your HbA1c (a measure of average blood sugar over 3 months) is above 6.5% **You may NOT be eligible if:** - You have chronic kidney disease - You have liver problems - You have a mental or psychiatric disorder - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSitagliptin 100mg

Sitagliptin is used along with diet and exercise and sometimes with other medications to lower blood sugar levels in adults with type 2 diabetes

DRUGDoxycyclin

Doxycycline belongs to the class of medicines known as tetracycline antibiotics. It works by killing bacteria or preventing their growth.


Locations(1)

Tanta Unuversity

Tanta, Egypt

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NCT06329882


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