Imaging in Moyamoya Disease - Study to Investigate Different Imaging Technologies for a Better Understanding of Various Imaging Techniques to Evaluate Cerebral Hemodynamics, Disease-activity and Possibly the Etiology in Moyamoya Patients
IMAGINE - Imaging in Moyamoya Disease
University Hospital Tuebingen
50 participants
Jul 1, 2024
INTERVENTIONAL
Conditions
Summary
Aim of this study is to improve patient care in Moyamoya Patients by improving Imaging technologies and aiming to identify factors involved in disease progression. Main tasks are: * Analysis of CO2-triggered BOLD fMRI for analysis of cerebral hemodynamics in comparison to H2 15O PET/CT * Analysis of longitudinal changes of contrast enhancement in vessel-wall imaging and correlation of disease activity with biosampling * Definition of a standardized recommendation for pre- and postoperative imaging of Moyamoya patients
Eligibility
Inclusion Criteria2
- Patients with suspicion of Moyamoya Disease
- Patients able to understand the study and to give their informed consent
Exclusion Criteria7
- Cerebral vascular disease caused by atherosclerosis
- Vasculitis
- Contraindications to MRI
- Contraindications to PET/CT
- Pregnancy
- Inability to give informed consent
- Renal insufficiency
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Interventions
Patients will get special MRI sequences (CO2-triggered BOLD MRI, Vessel-wall imaging, resting state BOLD MRI) to identify cerebral vasoreactivity and disease activity.
Patients will get H2 15O PET/CT with acetazolamide challenge to define the cerebral vasoreserve for comparison with fMRI Images
Patients do get a venous puncture for blood analysis on circulating endothelial cells and virus PCR analysis
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06330818