RecruitingNCT06331130

Mesenteric Infiltration in Ovarian Cancer

CT Detected Tumour Infiltration Patterns of the Mesentery in High Grade Ovarian Carcinoma (HGSOC) Patients, Their Role in Treatment Planning and Outcome Prediction and How Machine Learning Can be Applied to Identify Them.

Sponsor

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Enrollment

510 participants

Start Date

Mar 1, 2024

Study Type

OBSERVATIONAL

Conditions

Ovary Cancer

Summary

To evaluate if CT features at diagnosis in patients with HGSOC can be used to build an Artificial Intelligence model capable of discerning the pathological involvement of the mesentery, assessing the potential impediments for an optimal debulking surgery and predicting the development of resistance to platinum based chemotherapeutic agents.

Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how involvement of the mesentery (the tissue connecting the intestines to the abdominal wall) in ovarian cancer affects surgical outcomes and treatment decisions. High-grade serous ovarian cancer commonly spreads to the mesentery, and researchers want to better understand the extent of this spread and how to plan the most effective surgery. **You may be eligible if:** - You are a woman with confirmed high-grade serous ovarian cancer (HGSOC) that has spread to the mesentery - You are 18 or older - Your cancer is at stage IIIB or higher (advanced) - This is your first (primary) diagnosis, before any chemotherapy **You may NOT be eligible if:** - Your ovarian cancer is a different type (such as low-grade, mucinous, clear cell, endometrioid, or non-epithelial) - Your cancer is at an early stage (stage I or II) - A CT scan is not available for review - You have previously received neoadjuvant (pre-surgery) chemotherapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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