RecruitingPhase 2NCT06333652

Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders

Clinical Trial on the Use of Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders


Sponsor

Mayo Clinic

Enrollment

14 participants

Start Date

Sep 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The researchers are testing a medication named ravulizumab for the treatment of severe preeclampsia and Hemolysis, Elevated Liver enzymes, Low Platelets (HELLP) syndrome.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a drug called ravulizumab — which blocks part of the immune system — can help pregnant women who develop severe high blood pressure complications (such as severe preeclampsia or HELLP syndrome) before 34 weeks of pregnancy. These dangerous conditions can harm both mother and baby. **You may be eligible if...** - You are pregnant and less than 34 weeks along - You have been diagnosed with severe preeclampsia or HELLP syndrome (a serious condition involving high blood pressure, liver problems, and low platelets) **You may NOT be eligible if...** - You have developed a dangerous blood-clotting disorder (DIC) - Your baby is showing signs of distress that require immediate delivery - Your pregnancy is before 23 weeks or a fetal death has occurred - You have certain blood or immune conditions (such as atypical HUS, TTP, or PNH) - You are allergic to ravulizumab - You are unable or unwilling to give informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGRavulizumab

Intravenous infusion 100 mg/ml


Locations(1)

Mayo Clinic Minnesota

Rochester, Minnesota, United States

View Full Details on ClinicalTrials.gov

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NCT06333652


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