RecruitingNot ApplicableNCT06334224

Acute Physiological Responses to Twice Daily Blood Flow Restriction Training

Effects of Twice Daily Blood Flow Restriction Training on Muscle Swelling, Markers of Exercise Induced Muscle Damage and Inflammation: A Randomised Control Trial

Sponsor

Defence Medical Rehabilitation Centre, UK

Enrollment

18 participants

Start Date

Nov 6, 2023

Study Type

INTERVENTIONAL

Conditions

Muscle Weakness Muscle Damage

Summary

The Academic Department of Military Rehabilitation (ADMR) is currently conducting a pan-defence, randomised control trial (RCT) investigating the utility of twice daily blood flow restriction training in UK military personnel with persistent knee pain (NCT05719922). Due to logistical confinements, this pan-defence RCT is confined to collecting outcome data pre and post-intervention. Therefore, the acute physiological mechanisms which underpin adaptation will remain unknown. Consequently, ADMR is undertaking an additional, single centre RCT which will compare the acute physiological responses to low load resistance training with and without the addition of blood flow restriction. Specifically, this study will elucidate the effect of twice daily blood flow restriction training on measures of muscle swelling, muscle damage and inflammation. This data may aid in the optimisation of blood flow restriction exercise prescription within UK Defence Rehabilitation and elsewhere.

Eligibility

Min Age: 18 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how the body responds to doing blood flow restriction training (BFR) — where a cuff partially limits blood flow to the muscles during low-intensity exercise — twice per day. Researchers want to understand the short-term physiological effects of this training frequency. **You may be eligible if...** - You are between 18 and 55 years old - You work at the Defense Medical Rehabilitation Centre (DMRC) as a civilian or service member - You have not done regular lower-body resistance training in the past 6 months **You may NOT be eligible if...** - You have a current lower-limb injury - You have cardiovascular disease or other serious health conditions - You have a medical reason that makes blood flow restriction unsafe - You have limited range of motion in your knee or other lower-limb joint problems - You are taking medications that affect blood flow or muscle recovery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICELow load resistance training with blood flow restriction

The intervention involves placing a pneumatic tourniquet system over the proximal thigh. The cuff is inflated to 80% of limb occlusion pressure during lower limb strengthening exercises. These exercises include leg press and knee extensor exercises. Four sets (30,15,15,15 repetitions) performed at 20% of one repetition maximum.

OTHERLow load resistance training

Leg press and knee extensor exercises. Four sets (30,15,15,15 repetitions) performed at 20% of one repetition maximum.

Locations(1)

Defence Medical Rehabilitation Centre

Loughborough, United Kingdom

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NCT06334224

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