Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness

This study is investigating the metabolic changes that occur in critically ill patients who develop Intensive Care Unit-Acquired Muscle Weakness (ICUAW) — a condition where prolonged mechanical ventilation and immobility lead to significant muscle loss and weakness. By analyzing metabolites in patients' blood and muscle tissue, researchers aim to better understand why this happens and how to prevent it. You may be eligible if: - You are 18 years old or older - You have undergone surgery and are now in intensive care on a mechanical ventilator - Your ICU stay is expected to last more than 3 days - You have an ASA classification of III or higher (meaning you have serious systemic disease) You may NOT be eligible if: - You are considered a moribund patient (actively dying) - You are receiving comfort-only or palliative care rather than curative treatment Talk to your family or healthcare proxy about whether participation in this observational study aligns with your wishes during intensive care.