Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness
Metabolomics Pilot Study on Postoperative Intensive Care Acquired Muscle Weakness (MIRACLE-I Study)
Technical University of Munich
20 participants
Sep 2, 2022
OBSERVATIONAL
Conditions
Summary
In this mono-center pilot trial, surgical patients who are at high risk to be admitted to intensive care will be screened and asked for participation. We are going to take blood and muscle samples at respecified time points to do metabolic, histological and molecular testing. Aim of the study is to investigate (1) changes of the blood metabolome in patients with ICUAW (intensive care unit acquired weakness) and (2) identify metabolic components who are responsible for ICUAW or can be used as marker for ICUAW.
Eligibility
Inclusion Criteria4
- invasive mechanically ventilated critically ill patient with expected intensive care unit stay \> 3 days
- postoperative patient
- ≥ 18 years old
- American Society of Anesthesiology (ASA) classification ≥ III
Exclusion Criteria2
- moribund patient
- non-curative care (comfort care)
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Locations(3)
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NCT03810768