Molecular Signatures Associated With Response to ICS Treatment in Patients With COPD Stratified by Eosinophil Levels

This study is looking at which biological markers (patterns in genes, proteins, or immune cells) in the airways predict whether patients with COPD (chronic obstructive pulmonary disease) will benefit from inhaled corticosteroids (ICS) — a common type of inhaled medication. **You may be eligible if...** - You are 40 years or older - You are a former smoker (quit at least 6 months ago) with at least a 10 pack-year smoking history - You have confirmed COPD (a breathing test showing obstruction) - Your lung function is in the moderate-to-severe range (FEV1 between 30–80% of predicted) - You have been on two long-acting bronchodilator inhalers (LABA+LAMA) for at least 8 weeks **You may NOT be eligible if...** - You are currently smoking - You have had a COPD flare-up recently - You are pregnant or unable to use effective contraception - You are on inhaled steroids or have taken oral steroids recently - You have significant other lung or immune conditions Talk to your doctor to see if this trial is right for you.