RecruitingNot ApplicableNCT06334952

Efficacy of Personnalized Transcranial Direct Current Electrical Stimulation (tDCS) in Drug-resistant Epileptic

Model-based Multichannel Transcranial Direct Current Electrical Stimulation (tDCS) in Drug-resistant Epilepsy: A Cross-over Study of Efficacy


Sponsor

Assistance Publique Hopitaux De Marseille

Enrollment

60 participants

Start Date

Dec 18, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to to obtain a significant decrease in seizure frequency in patients with refractory focal epilepsy after applying treatment of cathodal tDCS, compared to sham stimulation drug-resistant epileptic patient. The main questions it aims to answer are: * Changes in quality of life * Percent of newly reported side effects after the stimulation period * Scores in epilepsy severity. Participants will be randomized in a cross-over, and will receive 10 days of tDCS or Sham. Each day will allow 2 periods of 20 minutes stimulation separated by 20 minutes off (with 40 minutes of cathodal stimulation total).


Eligibility

Min Age: 9 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a medical device called transcranial direct current stimulation for people with drug resistant epilepsy and epilepsy. The study is currently recruiting participants at 7 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEtranscranial direct current stimulation

Research MRI includes 3D-T1 weighted MRI (3D-T1), diffusion MRI (dMRI), resting-state functional MRI (rsfMRI).


Locations(7)

Service de Neurophysiologie Clinique de l'Enfant et de L'Adulte, Pôle de Neurosciences Cliniques

Bordeaux, France

Département Neurologie Fonctionnelle et Epilepsie, Hôpital neurologique - Hospices Civils de Lyon

Bron, France

Service de Neurophysiologie clinique - Hôpital Roger Salengro, CHU Lille

Lille, France

Service Epileptologie et Rythmologie Cérébrale, Hôpital La Timone

Marseille, France

Service de Neurophysiologie clinique - GHU Psychiatrie et Neurosciences Sainte-Anne

Paris, France

Service de Neurologie - CHU de Rennes - Hôpital Pontchaillou

Rennes, France

Explorations neurophysiologiques - Pôle neurosciences, CHU de Toulouse, Hôpital Pierre Paul Riquet

Toulouse, France

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NCT06334952


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