RecruitingNot ApplicableNCT06335420

Prophylactic Properties of Carrot Juice in Patients With High-Risk Colorectal Polyps

Polyp Prophylactic Properties of Polyacetylenes in Patients With Previous Polypectomy


Sponsor

Odense University Hospital

Enrollment

400 participants

Start Date

Jun 20, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this prospective randomized double-blinded bi-national study is to test the prophylactic effect of polyacetylenes from carrots on the population of patients who had a resection of high-risk adenomas of the large bowel. The main question it aims to answer is: Will carrot juice rich in polyacetylenes inhibit neoplastic transformation and growth in high-risk humans? Participants will have to drink 100 ml of juice daily after the adenoma resection for 1 year and keep a simple diary/calendar. Researchers will compare the group with ingestion of Falcarinol (FaOH) / Falcarindiol (FaDOH) rich carrot juice versus the group consuming placebo juice, to see if the polyacetylenes significantly reduces neoplastic transformation and growth in high-risk patients.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether drinking carrot juice daily can reduce the risk of developing new colon polyps (growths that can turn into cancer) in people who have already had large polyps or early cancers removed during colonoscopy. **You may be eligible if...** - You recently had a large colon polyp (20 mm or larger) or a T1 colorectal cancer removed during a colonoscopy - You are able and willing to follow the study's treatment and follow-up schedule **You may NOT be eligible if...** - You were placed in a high-risk group because you had many small polyps (more than 4) - You are pregnant - You have known food allergies relevant to the study - You regularly take anti-inflammatory medications (like aspirin, ibuprofen, or celecoxib) or immunosuppressants - You are currently receiving cancer treatment (chemotherapy, radiation, or immunotherapy) for another cancer - You have severe heart failure (NYHA class III–IV) or Lynch syndrome Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIETARY_SUPPLEMENTCarrot juice from Yellowstone carrots cultivars

Consumption of 100 ml of carrot juice daily for 1 year

DIETARY_SUPPLEMENTPlacebo juice

Consumption of 100 ml of placebo juice daily for 1 year


Locations(1)

Department of Surgery, Odense University Hospital

Odense, Denmark

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06335420


Related Trials