RecruitingPhase 1NCT07095517

Pathways, Risk Factors, and mOleculeS to Prevent Early-onset Colorectal Tumors

Sponsor

Massachusetts General Hospital

Enrollment

20 participants

Start Date

Feb 24, 2026

Study Type

INTERVENTIONAL

Conditions

Colorectal Adenoma Colorectal Cancer Prevention

Summary

This research study is an open-label Phase 1 Exploratory/Pilot clinical trial to measure the effects of the incretin mimetic, tirzepatide, on tissue, urine, blood, and microbiome biomarkers associated with colorectal cancer risk and to understand the feasibility of this precision prevention trial approach for a future larger study.

Eligibility

Min Age: 18 YearsMax Age: 50 Years

Inclusion Criteria5

Age 18-50 years Because no dosing or adverse event data are currently available on the use of tirzepatide in participants \<18 years of age, children are excluded from this study. Because we are specifically studying the prevention of EOCRC, which is defined as CRC occurring prior to age 50, the study population will only enroll participants under the age of 50 at baseline.
BMI between 27 and 40 kg/m2
Underwent a screening or surveillance colonoscopy within the prior 9 months.
Removal of multiple (at least 2) colon or rectal adenomas (including sessile serrated adenomas but excluding hyperplastic polyps) or a single adenoma ≥6mm in size during the last colonoscopy
Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria10

Participants who have ever taken incretin mimetic therapies.
Participants with a history of medullary thyroid cancer or MEN 2 syndrome.
Participants at high risk of pancreatitis or otherwise contraindicated for use of tirzepatide according to clinical labeling.
Participants with a history of cancer (excluding non-melanoma skin) within the last three years
Participants with a history of diabetes mellitus
Participants with a history of bowel surgery
Participants with hereditary cancer syndromes, including HNPCC/Lynch syndrome or familial adenomatous polyposis
Participants with a history of inflammatory bowel disease, Crohn's, or colitis.
Participants with incomplete or partial polypectomy during prior colonoscopy.
Participants who are pregnant. Participants who may become pregnant or partners of those who may become pregnant while on study will receive contraception counseling. Participants or partners of those who become pregnant while participating on the study should immediately inform their doctor.