Antibacterial Tactics Based on Presepsin Level in Thoracic Aorta Surgery Patients
Changes in Antibacterial Therapy Based on Perioperative Dynamics of Presepsin During Reconstructive Thoracic Aorta Surgery
Petrovsky National Research Centre of Surgery
50 participants
Jan 23, 2024
INTERVENTIONAL
Conditions
Summary
According to the literature, presepsin was recommended not only as an effective indicator in the diagnosis of sepsis in intensive care units, but also as a reliable prognostic marker of postoperative inflammatory processes in cardiac surgery. Previous study carried out in Petrovsky NRCS related to biomarkers in cardiac surgery and presepsin in particular showed good sensitivity in infection complications prognosis.
Eligibility
Inclusion Criteria1
- Thoracic aorta aneurysm/dissection
Exclusion Criteria1
- Blood sample hemolysis
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
If a patient meets dual criteria (presepsin \> 519,5 pg/ml at the end of surgery and the absence of presepsin increase after 6 hours after the end of surgery) then switching to ampicillin/sulbactam 3 g every 6 hours at least 72 h after the surgery is done.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06336213