RecruitingNot ApplicableNCT06337357

Results of Progressive Resistance Training in Older Type 2 Diabetic Patients With Sarcopenia

Evaluating Resistance Training for Sarcopenia in Older Patients With Type 2 Diabetes: Treatment Outcomes

Sponsor

National Geriatric Hospital

Enrollment

80 participants

Start Date

Apr 1, 2024

Study Type

INTERVENTIONAL

Conditions

Sarcopenia Diabetes

Summary

A randomized controlled clinical trial that will test how progressive resistance training will impact outcomes of sarcopenia in older patients with type 2 diabetes who have been diagnosed as sarcopenia. The intervention will be 12 weeks in duration with approximately 24 sessions of resistance exercises. Outcome measures will be collected at baseline, 4, 8 weeks and 12 weeks.

Eligibility

Min Age: 60 YearsMax Age: 80 Years

Inclusion Criteria4

Type 2 diabetic patients diagnosed using American Diabetes Association 2022 criteria
HbA1c ≥ 7.0 and ≤ 8.5%
Sarcopenia diagnosed using criteria from the Asian Working Group for Sarcopenia 2019
Age ≥ 60 and ≤ 80

Exclusion Criteria7

Acute diabetic complications
Patients are in the acute phase of musculoskeletal disorders: acute gout, progressing low-grade arthritis, acute joint pain due to joint degeneration, sciatic pain, and infectious arthritis.
Patients suffer from conditions significantly affecting cognition and mobility: sequelae of stroke (with weakness, limb paralysis), muscular weakness, limb disabilities, severe heart failure, severe cognitive decline, and psychiatric disorders.
Patients have been bedridden due to illness for more than 1 month within the past 3 months up to the recruitment time.
Patients with cardiovascular diseases: chest pain, uncontrolled blood pressure ≥160/100 mmHg, untreated cardiac arrhythmia, a history of congestive heart failure, severe valvular heart disease, myocarditis or pericarditis, and hypertrophic cardiomyopathy.
Renal failure with estimated glomerular function rate (Modification of Diet in Renal Disease equation) \< 60 ml/min/m3 or serum creatinine ≥ 130 µmol/l
On treatment with Sodium-glucose cotransporter 2 inhibitors (SGLT2i)

Interventions

BEHAVIORALProgressive Resistance Training

Progressive resistance training includes face-to-face education on resistance training: Resistance exercises with elastic bands include 9 exercises for 1 course. During the first 4 weeks, the patient exercises twice a week with a level of exertion according to Borg's category-ratio 10 (CR10) scale of 4-5 points. For the next 4 weeks, the patient exercises twice a week with Borg's CR10 exertion level of 6-7 points. In the last 4 weeks, the patient exercises twice a week with Borg's CR10 exertion level of 8-9 points. The three-month intervention involves twelve weekly calls, with a focus on building rapport (e.g. providing feedback on the baseline assessment); education reinforcement on resistance training; and skill-building (e.g. self-monitoring and resistance training diary). The emphasis is on helping participants to gain the knowledge and skills necessary to achieve targeted intensity. Every 4 weeks, all patients are re-visited by investigators in the hospital.