Survival With Olanzapine in Patients With Locally Advanced or Metastatic Upper Gastrointestinal and Lung Cancer

This study investigates whether olanzapine — a medication typically used for psychiatric conditions but also known to improve appetite — can help patients with advanced stomach, esophageal, liver, pancreatic, bile duct, or lung cancer maintain their weight and survive longer during palliative chemotherapy. **You may be eligible if...** - You are 18 or older - You have stage III or IV inoperable or metastatic cancer of the stomach, esophagus, liver/pancreas/bile ducts, or lung, confirmed by biopsy - You are receiving or will receive palliative chemotherapy - You are expected to live at least 3 months - You can take oral medications without dietary restrictions **You may NOT be eligible if...** - Your weight changes are due to fluid buildup (edema or ascites) - You have a mental health condition or are taking antipsychotic or antidepressant medications - You have brain metastases, epilepsy, or other central nervous system disorders - You use sedatives long-term, are on long-term hormone therapy, or have chronic alcoholism or substance dependence - Olanzapine is medically contraindicated for you - You have a history of low white blood cell counts caused by clozapine - You have uncontrolled diabetes or seizures - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.