Neurofilament Light Chain And Voice Acoustic Analyses In Dementia Diagnosis
A Blood Test for Dementia? A Cohort Study to Assess the Diagnostic Utility of Plasma Neurofilament Light Chain Protein in All-cause Dementia
Monash University
1,000 participants
Aug 1, 2021
OBSERVATIONAL
Conditions
Summary
This cohort study aims to determine if a blood test can aid with diagnosing dementia in anyone presenting with cognitive complaints to a single healthcare network. The investigators will measure levels of a brain protein, Neurofilament light chain (Nfl), and assess changes in language using speech tests. Participants will have a single blood test and speech test, and will be followed up at 12-months to complete questionnaires and cognitive scales over the phone. The speech test will also be completed again at 12-months. Individuals at risk of a Fronto-temporal dementia syndrome will be eligible to complete optional genetic testing involving an 'at home' saliva sample.
Eligibility
Inclusion Criteria1
- All patients presenting to Eastern Health services with a cognitive complaint or potential neurodegenerative disorder
Exclusion Criteria3
- Prognosis \<12 months
- No cognitive complaint
- Patients not involved within the single healthcare network
Interventions
A single blood draw at the time of presentation to clinic or whilst an inpatient.
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT06339190