RecruitingNCT06339190

Neurofilament Light Chain And Voice Acoustic Analyses In Dementia Diagnosis

A Blood Test for Dementia? A Cohort Study to Assess the Diagnostic Utility of Plasma Neurofilament Light Chain Protein in All-cause Dementia

Sponsor

Monash University

Enrollment

1,000 participants

Start Date

Aug 1, 2021

Study Type

OBSERVATIONAL

Conditions

Dementia Neurodegenerative Diseases

Summary

This cohort study aims to determine if a blood test can aid with diagnosing dementia in anyone presenting with cognitive complaints to a single healthcare network. The investigators will measure levels of a brain protein, Neurofilament light chain (Nfl), and assess changes in language using speech tests. Participants will have a single blood test and speech test, and will be followed up at 12-months to complete questionnaires and cognitive scales over the phone. The speech test will also be completed again at 12-months. Individuals at risk of a Fronto-temporal dementia syndrome will be eligible to complete optional genetic testing involving an 'at home' saliva sample.

Eligibility

Plain Language Summary

Simplified for easier understanding

This study explores whether measuring a blood protein called neurofilament light chain (NfL) — a marker of brain cell damage — combined with analyzing voice characteristics can help diagnose dementia and other brain disorders earlier and more accurately. **You may be eligible if...** - You are a patient at Eastern Health services with a memory complaint or concern about a possible neurodegenerative disease (e.g., dementia, Parkinson's) **You may NOT be eligible if...** - Your life expectancy is less than 12 months - You have no cognitive complaint or concern - You are not a patient within the Eastern Health network Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTVenepuncture

A single blood draw at the time of presentation to clinic or whilst an inpatient.

Locations(2)

Box Hill Hospital

Box Hill, Victoria, Australia

Wantirna Health

Wantirna, Victoria, Australia

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NCT06339190

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