RecruitingPhase 2NCT06339580
Assessment of Volume-targeted Ventilation in Patients With Neuromuscular Disease
A Proof-on-concept Study to Investigate the Potential Use of Volume-targeted Ventilation in Patients With Slowly Progressive Neuromuscular Disease
Sponsor
Guy's and St Thomas' NHS Foundation Trust
Enrollment
30 participants
Start Date
Apr 9, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
Assessment of safety and efficacy of volume-targeted ventilation in patients with neuromuscular disease.
Eligibility
Min Age: 18 YearsMax Age: 80 Years
Inclusion Criteria3
- Slowly progressive neuromuscular disease
- Established on fixed bi-level ventilation
- Documented clinical respiratory stability by supervising clinician (no hospitalizations, respiratory infections or change to ventilator settings in preceding 6 weeks)
Exclusion Criteria6
- Rapidly progressive neuromuscular disease
- Decompensated respiratory failure (pH < 7.35)
- Pregnancy
- Aged <18, >80
- Poor adherence to NIV (<4hrs per night)
- Significant physical or psychiatric co-morbidity that would prevent compliance with trial protocol
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Interventions
DEVICEVolume-targeted non-invasive ventilation
A target tidal volume is set on the ventilation device, and the device will then automatically adjust delivered pressures to reach this target tidal volume.
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06339580
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