RecruitingNot ApplicableNCT06346054

Molecular Assessment for Gastro-Esophageal Cancer


Sponsor

KU Leuven

Enrollment

1,000 participants

Start Date

Aug 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this minimally invasive interventional study is to learn if oncometabolic biomarkers, detected in the exhaled breath and blood can identify early-stage gastro-oesophageal cancer in patient at risk for gastro-oesophageal cancer. The main questions this study aims to answer: Are oncometabolites proficient and reproducible enough to function as diagnostic biomarkers? Can these biomarkers identify early-stage gastro-esophageal cancer? Researchers will compare participants with gastro-oesophageal cancer to healthy controls and participants with Barrett's esophagus to detect meaningful differences between the groups. Participants will provide a breath and blood sample during their routine standard of care visits.


Eligibility

Min Age: 18 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether breath and blood samples can be used to detect stomach and esophageal cancer at an early stage or to identify pre-cancerous conditions like Barrett's esophagus. Researchers will analyze molecules in exhaled breath and blood for patterns linked to cancer. **You may be eligible if...** - You are over 18 years old - You have been diagnosed with Barrett's esophagus or gastro-esophageal cancer (any stage, untreated) - OR you are a healthy volunteer willing to donate a breath or blood sample for comparison **You may NOT be eligible if...** - You have another active cancer - You had a prior cancer treated less than 3 years ago - You have significant liver failure - You are incarcerated Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTBreath analysis

Detection of proteins and volatile organic compounds (oncometabolites) in the exhaled breath

DIAGNOSTIC_TESTBlood analysis

Detection of proteins and circulating tumor DNA (oncometabolites) in the peripheral blood


Locations(1)

University Hospitals Leuven

Leuven, Belgium

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NCT06346054


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