RecruitingPhase 2NCT06352008

To Evaluate the Efficacy and Safety of Anlotinib Hydrochloride Capsule in Postoperative Non-pCR Patients With Non-small Cell Lung Cancer


Sponsor

Tianjin Medical University Cancer Institute and Hospital

Enrollment

64 participants

Start Date

Jul 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

To explore the effectiveness of anlotinib hydrochloride capsule in postoperative non-pCR non-small cell lung cancer patients with adjuvant intensive therapy


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether anlotinib — a targeted anti-cancer drug that blocks tumor blood vessel growth — helps prevent cancer recurrence in people with non-small cell lung cancer (NSCLC) who did not achieve complete tumor eradication (called pathological complete response, or pCR) after pre-surgery immunotherapy plus chemotherapy. **You may be eligible if...** - You are 18 or older and have stage IIA–IIIA non-small cell lung cancer - You received pre-surgery treatment combining PD-1/PD-L1 immunotherapy with chemotherapy - You had surgery to completely remove the tumor (R0 resection) - Your tumor was not completely destroyed by the pre-surgery treatment - You are in good general health (ECOG 0 or 1) with an expected survival of at least 3 months **You may NOT be eligible if...** - You achieved complete tumor elimination (pCR) after pre-surgery treatment - You have serious heart, liver, or kidney problems - You have active bleeding or uncontrolled high blood pressure - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAnlotinib

12mg once a day, taken orally before breakfast for 2 consecutive weeks and stopped for 1 week. Without special circumstances, it is recommended to take at a fixed time every day; If there is a missing dose during the administration, confirm that the time before the next administration is less than 12 hours, no more refilling. The maximum duration of drug use is tentatively 1 year.


Locations(1)

Tianjin Medical University Cancer Institute & Hospital

Tianjin, China

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NCT06352008


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