RecruitingNCT06356207

Syncope-Asystole Latency Time in Tilt Table Test: The SALT-TILT Study

NeuroArrhythmias Area Registry of AIAC (NAARA) Syncope-Asystole Latency Time in Tilt Table Test (SALT-TILT) Study


Sponsor

Azienda Ospedaliera di Bolzano

Enrollment

64 participants

Start Date

Mar 20, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Syncope is a common presenting condition. Pacemaker implantation can significantly reduce syncope recurrences in reflex syncope. However, despite careful selection, a substantial proportion of patients treated with pacemakers suffer recurrences of syncope. It is thought that a pronounced vasodepressor component may hinder the efficacy of pacing in patients, preventing adequate cerebral perfusion during the reflex, thus relativizing the anti-bradycardia function of the pacemaker to prevent syncope. It is hypothesised that the time elapsed from the actual loss of consciousness to the asystole recorded on the ECG during Tilt Table Test may be predictive in terms of response to pacemaker therapy, so this parameter becomes the subject of the present study.


Eligibility

Min Age: 18 Years

Inclusion Criteria2

  • Patients eligible for invasive treatment according to the ESC Guidelines for pacing 2021
  • Written informed consent

Exclusion Criteria4

  • Other condition which explains syncope cause other than reflex syncope
  • Structural heart disease (valvular, ischaemic, cardiomyopathies)
  • Pregnancy
  • Patient denial to be recorded on video during tilt table test

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Interventions

DIAGNOSTIC_TESTTilt Table Test

The main goal of the study is to evaluate the time elapsed between the T-LOC during Video Tilt Table Testing and the asystole at the ECG using a national registry and to assess its predictive value in patients undergoing invasive treatment. The hypothesis is that a vasodepressive component could lessen the effect of pacing in a patient, leading to cerebral hypoperfusion and syncope despite maintaining a stable rhythm.


Locations(1)

Azienda Sanitaria di Bolzano

Bolzano, Italy

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NCT06356207


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