STRatIfication of Vulvar SCC by HPV and p53 Status to Guide Excision

This study is looking at whether the HPV virus status and a specific protein (p53) in vulvar cancer tissue can help guide how far surgical margins need to be when removing the tumor. The goal is to reduce the risk of cancer coming back while also minimizing unnecessary surgery. **You may be eligible if...** - You are 18 or older - You have been diagnosed with early-stage vulvar squamous cell carcinoma (FIGO Stage I or II) - You have had surgery to remove the tumor according to standard guidelines - You are able to complete quality-of-life questionnaires in English or French **You may NOT be eligible if...** - Your vulvar cancer is a recurrence (it came back after previous treatment) - Your cancer is not squamous cell carcinoma (a different cell type) - You have already received or are receiving adjuvant radiation or chemotherapy - You were treated at a center that did not follow standard surgical margin guidelines Talk to your doctor to see if this trial is right for you.