RecruitingNot ApplicableNCT06361407

Sensory and Cognitive Predictions, and Their Disruptions in Schizophrenia

Sponsor

Centre Psychothérapique de Nancy

Enrollment

68 participants

Start Date

Jun 28, 2024

Study Type

INTERVENTIONAL

Conditions

Sensory Processing Disorder Schizophrenia

Summary

Disturbances in the sense of self and time could play an important role in the development of psychotic symptoms. Previous work has shown that patients have difficulty preparing to process information on the scale of a second, but are abnormally disturbed by slightly asynchronous information on the millisecond scale. In both cases, the anomalies could explain the patients' unusual experience of time. The hypothesis in neurotypical patients is that small delays or asynchronies asynchronies are treated as irrelevant information and ignored and ignored, whereas in patients suffering from schizophrenia they would disrupt the flow of time. This hypothesis is tested with a new visual illusion.

Eligibility

Min Age: 18 YearsMax Age: 60 Years

Inclusion Criteria4

Male or female;
Age between 18 and 60 inclusive;
Subject having dated and signed the consent form prior to the start of any trial-related procedure (guardian or curator where applicable);
Member of a social security scheme or beneficiary of such a scheme.

Exclusion Criteria9

Psychoactive substance use disorders (as defined by the DSM-V) (Diagnostic and Statistical Manual-V);
Use of benzodiazepines, hallucinogens (in the period preceding before inclusion, for a duration equivalent to 5 half-lives of the product) or cannabis (in the 2 months preceding inclusion);
Neurological pathology or sequelae;
Attention deficit hyperactivity disorder (ADHD);
Borderline personality disorder;
Disabling sensory disorders (visual acuity \<0.8);
Person deprived of liberty or under court protection;
Pregnant, parturient or breast-feeding women;
Subjects in a period of exclusion defined by another clinical study.

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Interventions

BEHAVIORALIllusion task

The task is the illusion already described in the arm description. All participants will additionally benefit from a short neuropsychological evaluation exploring attention (CPT-AX) and semantic knowledge (fNART) and a clinical evaluation exploring the sense of self (EASE).