RecruitingNot ApplicableNCT06036316

Study of Language Disorders and Interactions Between Mnesic Capabilities and Semantic Competencies in Patients With Psychosis


Sponsor

Centre Psychothérapique de Nancy

Enrollment

90 participants

Start Date

Jan 23, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This research concerns the study of language disorders of patients present in the spectrum of psychosis. It is indeed accepted that psychotic disorders are associated with language difficulties, which are only poorly highlighted thanks to reusable tools in clinical practice. These language disorders impact communication, and concern many linguistic domains, thus covering phonology, lexicon, semantics, morphosyntax and pragmatics. It therefore seems relevant to characterize these language disorders and to assess to what extent they interact with the other symptoms of the pathology, in particular the course of the thought disorder and the neuropsychological symptoms. In addition, this study is particularly interested in the interactions between working memory capacities and those related to syntax. It is intended for different patients suffering from psychotic disorders of different intensities, treated in the Psychotherapeutic Center of Nancy. Patients suffering from at-risk mental state (ARMS), first episode of psychosis (FEP) or schizophrenia will benefit from a complete language assessment, evaluating each domain mentioned above, on the expressive and understanding sides. The results of the language assessment will be compared with those of a control group in the same tests. They will also be analyzed with regard to the neuropsychological and psychiatric elements noted in the patient's medical file, in order to highlight possible associations between language skills, neuropsychological and psychiatric symptoms in this patient population.


Eligibility

Min Age: 16 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how language, memory, and thinking skills are affected in people with psychosis (including schizophrenia) or those at high risk of developing it, using various language and memory tests. Healthy volunteers also participate for comparison. **You may be eligible if...** - You are between 16 and 55 years old (or 16–35 for high-risk and first-episode groups) - You are a native French speaker - You have been diagnosed with schizophrenia, are experiencing your first psychotic episode, or are at high risk of psychosis — OR you are a healthy volunteer - Minors must have parental consent **You may NOT be eligible if...** - You are pregnant or breastfeeding - You are under guardianship or deprived of liberty - You have a substance abuse or dependence disorder (excluding cannabis) - You have cognitive or communication difficulties that would prevent participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALLanguage assessment

The proposed speech and language therapy assessment will consist of a battery of standardized tests that speech and language therapists can use to assess the language skills in reception and expression of adult patients. Concerning the assessment of the interactions between working memory and semantic abilities, a complete protocol has been developed.

BEHAVIORALTLC - Scale for the Assessment of Thought, Language, and Communication

This scale is frequently used in psychiatry and is used to measure formal thought disorders in patients suffering from psychosis. As part of this study, it will be intended for patients suffering from schizophrenia

BEHAVIORALMINI - Mini International Neuropsychiatric Interview

This scale corresponds to a rapid assessment of the psychiatric and psychological state of patients. It helps detect any psychiatric disorders. Here, it will be offered to volunteers who are part of the control group.

COMBINATION_PRODUCTCAST - Cannabis Abuse Screening Test

The purpose of this questionnaire is to approximate participants' cannabis consumption and to assess any disorders associated with cannabis consumption. It will be offered to all participants, patients and healthy controls


Locations(1)

Centre Psychothérapeutique de Nancy

Laxou, France, France

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NCT06036316


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