RecruitingNot ApplicableNCT06363981

Multisite rTMS for Mood, Cognitive Impairment and Other Symptoms of Depression

Multisite Repetitive Transcranial Magnetic Stimulation for Mood, Cognitive Impairment, Anhedonia and Disordered Sleep in Depressive Disorder


Sponsor

Jakub Antczak

Enrollment

90 participants

Start Date

May 20, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Depressed mood is the main symptom of depression, but other symptoms like cognitive impairment, anhedonia or sleep disorders may also contribute to patients suffering and are difficult to treat. rTMS is a relatively novel treatment option, whose therapeutic potential is still investigated and optimized. The aim of this study is to assess the effect of rTMS applied over two stimulation sites on cognitive impairment, anhedonia and sleep disorders in depression.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study tests repetitive transcranial magnetic stimulation (rTMS) — a non-invasive brain stimulation treatment — applied to multiple brain areas to treat moderate-to-severe depression that also involves sleep problems, memory difficulties, and concentration issues. **You may be eligible if...** - You have a moderate-to-severe depressive episode (without psychotic features) - Your depression score is between 20 and 35 on the Hamilton Depression Rating Scale - You have significant sleep problems (Athens Insomnia Scale score ≥8) - You have noticeable memory and concentration problems related to your depression **You may NOT be eligible if...** - You have metal implants in your head, are pregnant, or have epilepsy (these are contraindications to brain magnetic stimulation) - You have psychotic symptoms - You had suicidal thoughts or attempts in the past 3 months Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DEVICEActive rTMS over the left DLPFC and over the left DMPFC

Active rTMS over the left DLPFC and over the left DMPFC to induce the long term potentiation of stimulated areas.

DEVICEActive rTMS over the left DLPFC

Active rTMS over the left DLPFC to induce the long term potentiation of stimulated area.

DEVICESham rTMS

Sham rTMS over the left DLPFC or over the left DLPFC and over the left DMPFC for placebo.


Locations(1)

The Education of Research and Development Center, Babinski Clinical Hospital

Krakow, Poland

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06363981


Related Trials