Multisite rTMS for Mood, Cognitive Impairment and Other Symptoms of Depression
Multisite Repetitive Transcranial Magnetic Stimulation for Mood, Cognitive Impairment, Anhedonia and Disordered Sleep in Depressive Disorder
Jakub Antczak
90 participants
May 20, 2024
INTERVENTIONAL
Conditions
Summary
Depressed mood is the main symptom of depression, but other symptoms like cognitive impairment, anhedonia or sleep disorders may also contribute to patients suffering and are difficult to treat. rTMS is a relatively novel treatment option, whose therapeutic potential is still investigated and optimized. The aim of this study is to assess the effect of rTMS applied over two stimulation sites on cognitive impairment, anhedonia and sleep disorders in depression.
Eligibility
Inclusion Criteria5
- severe or moderate depressive episode (according to international classification of diseases (ICD)-10) without psychotic symptoms at the time of inclusion
- Hamilton Depression Rating Scale between between 20 and 35 points at inclusion
- The score in the Athens Insomnia Scale eight or more
- The score of three or more points in items 4 and 21 of the Beck Depressions Inventory 2
- Complaining about problems with memory and concentration timely related with the onset of depression
Exclusion Criteria3
- Contraindications to transcranial magnetic stimulation, including ferromagnetic elements in head, pregnancy and epilepsy
- Psychotic symptoms at the time of inclusion
- Suicidal ideations and/or attempts within three months prior to inclusion
Interventions
Active rTMS over the left DLPFC and over the left DMPFC to induce the long term potentiation of stimulated areas.
Active rTMS over the left DLPFC to induce the long term potentiation of stimulated area.
Sham rTMS over the left DLPFC or over the left DLPFC and over the left DMPFC for placebo.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06363981