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RecruitingNCT06365372

Circulating MrgD in Pulmonary Hypertension

Circulating MrgD Change in Patients With Pulmonary Hypertension

Sponsor

Qilu Hospital of Shandong University

Enrollment

90 participants

Start Date

Apr 10, 2024

Study Type

OBSERVATIONAL

Conditions

Pulmonary Hypertension

Summary

The aim of the study is to observe the change of the circulating MrgD level in patients with pulmonary hypertension compared with subjects without pulmonary hypertension.

Eligibility

Min Age: 18 Years

Inclusion Criteria6

  • Male or female aged ≥18 years
  • Right heart catheterisation to check the mean pulmonary artery pressure (mPAP) ≥25mmHg
  • The patient is willing and able to provide written informed consent.
  • Male or female aged ≥18 years
  • No evidence of pulmonary hypertension on echocardiography or mean pulmonary artery pressure (mPAP) \< 25 mmHg on right heart catheterization, and no evidence of clinically relevant heart disease
  • No evidence of clinically relevant pulmonary disease

Exclusion Criteria17

  • Age less than 18 years old
  • Mean pulmonary artery pressure (mPAP) \<25mmHg
  • Unable to provide informed written consent for participation in the study
  • Renal insufficiency
  • Liver insufficiency
  • Malignant tumor
  • Active infection
  • Pregnancy
  • Age less than 18 years old
  • Mean pulmonary artery pressure (mPAP) ≥25mmHg
  • Unable to provide informed written consent for participation in the study
  • Symptoms of heart failure or clinically relevant lung disease
  • Renal insufficiency
  • Liver insufficiency
  • Malignant tumor
  • Active infection
  • Pregnancy

Interventions

DIAGNOSTIC_TESTWestern blot

Samples were measured by Western blot using a solution for the separation of lymphocytes from peripheral blood.

Locations(1)

Qilu Hospital of Shandong University

Jinan, Shandong, China

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NCT06365372

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