RecruitingPhase 4NCT06370000

Oral Azacitidine in Transplant-Eligible Patients With Acute Myeloid Leukemia (AML) Suffering From Health-Inequality

REMAIN1: Relapse Prevention With Maintenance Oral Azacitidine in Transplant Eligible Patients With Acute Myeloid Leukemia Not Proceeding to Transplant Due to Racial or Socioeconomic Disparities


Sponsor

Virginia Commonwealth University

Enrollment

12 participants

Start Date

Nov 7, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Test feasibility of an oral maintenance strategy for transplant eligible AML patients in first CR who are medically underserved or have a disadvantage in the CDC SDOH domains


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing an oral medication called azacitidine as a "maintenance" treatment for people with acute myeloid leukemia (AML) who are eligible for a bone marrow transplant but face health or access barriers to receiving one. The goal is to help keep the cancer in remission without an immediate transplant. **You may be eligible if...** - You have been diagnosed with AML (not the APL subtype, and FLT3-negative) - You have completed standard induction and consolidation chemotherapy and are in remission - Your doctor considers you eligible for a bone marrow transplant but you are experiencing health inequality barriers - You are able to take oral medication **You may NOT be eligible if...** - Your AML is the APL subtype or FLT3-positive - You are not in remission after chemotherapy - You have significant organ dysfunction that would make treatment unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGOral Azacitidine

Oral Azacitidine, 300mg PO Daily during days 1-14 of a 28 day cycle for up to 6 cycles.


Locations(1)

Virginia Commonwealth University

Richmond, Virginia, United States

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NCT06370000


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