Mechanisms of Acute Kidney Injury in Severe Infections
Uppsala University Hospital
15 participants
May 1, 2024
OBSERVATIONAL
Conditions
Summary
Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography. For marked water will be used for renal perfusion and a newly developed PET tracer molecule (11C-GW457427) with specific binding to neutrophil elastase which provides a measure of the amount of infiltrating neutrophils in the renal parenchyma for inflammation. The study is performed in a PET-CT camera where anatomical imaging takes place at the same time as the PET examinations.
Eligibility
Inclusion Criteria7
- Patients with sepsis and AKI
- > 30 years
- At least AKI stage 1 according to KDIGO where the last plasma creatinine is measured within 24 hours of the examination
- Healthy volunteers
- > 30 years
- No previously known kidney disease
- Normal plasma creatinine value
Exclusion Criteria4
- Chronic renal failure (CKD stage >3a) or dialysis
- Instability in vital functions that makes PET-CT examination unsuitable
- Claustrophobia or other reasons that make the patient unable to lie still during the examination.
- Pregnancy and breastfeeding
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Interventions
Assessment of blood flow with marked water and assessment of neutrophil presence with neutrophil elastase tracer + CT
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06372444